THE ROLE OF LYSOSOMAL ENZYMES IN THE PATHOGENESIS OF SHOCK:(3) INTRACELLUAR REDISTRIBUTION OF LYSOSOMAL HYDROLASES IN THE PANCREAS
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Adult mongrel dogs were subjected to hemorrhagic shock and small portions of the pancreas were repeatedly excised to determine the intracellular redistribution of lysosomal hydrolases. The tissue was homogenized and centrifused for the separation of cytoplasmic (S-2) and lysosomal (S-3) fractions. Acid hydrolases in cytoplasmic fraction were cited as free type and ones in lysosomal pellets as bound type. In the late stage of oligemic shock and terminal stage of re-transfusion, free type enzymes such as β-glucuronidase and cathepsin-D increased significantly, being associated with the elevation of plasma hydrolase activity. The ratio of free type to bound one were markedly elevated in the late course of the experiment. These results suggests that lysosomes in pancreas become fragile after certain period of ischemia.
- 北関東医学会の論文
北関東医学会 | 論文
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