MECHANISM OF ACTION OF ALDOSTERONE IN ADRENALECTOMIZED:MOUSE KIDNEY V ANTAGONISTIC EFFECTS OF CYCLOHEXIMIDE WITH ALDOSTERONE ON CARBONIC ANHYDRASE AND NA<SUP>+</SUP>-K<SUP>+</SUP>-ATP ASE ACTIVITIES IN THE KIDNEY AND URINARY EXCRETION OF SODIUM
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Effects of cycloheximide and aldosterone, alone or in combination, on kidney, liver and blood carbonic anhydrase activity, kidney Na<SUP>+</SUP>-K<SUP>+</SUP>-ATPase activity and on urinary excretion of sodium were investigated using normal and adrenalectomized mice to clarify the significance of above enzymes as a mediator of action of aldosterone on sodium excretion.<BR>1. In normal mice, cycloheximide decreased kidney and blood carbonic anhydrase activity. The inhibition rates are parallel with the increase of doses and the maximum effect was observed at 4 hr after treatment. Liver carbonic anhydrase and kidney ATPase activities were not affected by cycloheximide.<BR>2. In adrenalectomized mice, combined administration of cycloheximide inhibited the aldosterone-induced increase of kidney carbonic anhydrase activity and decrease of urinary excretion of <SUP>22</SUP>Na. Kidney ATPase activity was unaltered in above condition.<BR>3. In adrenalectomized mice, single injection of cycloheximide did not affect the enzyme activity and sodium excretion.
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