STUDIES ON THE MECHANISM OF THYROID HORMONE SECRETION
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概要
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We attempted to determine the mechanism of heterogeneity of thyroid hormone secretion as determined by susceptibility to thyroid proteolysis. Thyroid iodoprotein from rats fed a high-iodine diet (HID) or a low-iodine diet (LID) were labeled with radioiodine in vivo for periods ranging from 4 hr to several days. Standardized aliquots of labeled thyroid homogenates from rats with various treatments were digested for 4 hr with 1% pancreatin or with 0.003% pancreatin after 30 min pretreatment with mercaptoethanol (ME).<BR>Four hr labeled iodoprotein from HID and LID rats was equally susceptible to digestion with 1% pancreatin. However, such iodoprotein from LID rats was more susceptible to digestion with ME than that from HID rats. There was a progressive rise in the resistance to digestion in iodoprotein from HID, but only a slight increase in resistance in iodoprotein from HID rats, with increasing intervals up to 7 days. No change in the susceptibility to digestion of thyroid iodoprotein with time after labeling was seen in hypohysectomized LID rats in which thyroid secretion is known to proceed at an extremely slow rate.<BR>The data presented indicate that there are at least two types of iodinated thyroglobulin in the rat thyroid. One is readily susceptible to digestion and has a rapid turnover in the thyroid. The other is more resistant to digestion and as a slow rate of turnover.
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北関東医学会 | 論文
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