EFFECTS OF PROSTAGLANDIN E1 ON CORONARY AND SYSTEMIC HEMODYNAMICS IN ANESTHETIZED DOGS

概要

論文の詳細を見る
The effects of prostaglandin E1 on coronary and systemic circulations were studied in anesthetized open chest dogs. The prostagiandin E1 showed a potent dilatatory effect on the coronary as well as the peripheral vessels. Following the intravenous injection, the aortic blood flow was markedly increased, while the aortic pressure was significantly decreased. The coronary blood flow was markedly increased following the intracoronary injection of the prostaglandin E1. The increase in the diastolic coronary flow was more prominent than in the systolic coronary flow. Although the coronary blood flow was slightly increased immediately following the intravenous injection of the prostaglandin E1, the flow returned soon to the control level as the aortic pressure was decreased. A direct chronotropic effect of prostaglandin E1 could not be demonstrated in the present study. The heart rate remained unchanged following the intracoronary injection, although a slight but significant increase in the heart rate was observed when the prostaglandin E1 was injected intravenously. It was postulated that a significant increase in maximum dp/dt of the left ventricle following the intracoronary injection of the prostaglandin E1 might suggest the direct positive inotropic effect.
北関東医学会の論文