RADICAL GASTRECTOMY COMBINED WITH GASTRIC ARTERIAL INFUSION OF ANTI-CANCER AGENTS
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The operation is the best therapy of stmach cancer. 5-year suvival rates, however, have not reached 50% in any report, so we feel urged to additive treatment of this disease. Manuplation of surgery increases cancer cells in blood, causing recurrence of carcinoma, so as latent liver metastasis, vascular invasion, intramural metastasis and serosa infiltration.<BR>Since 1962, we have tried gastric arterial infusion of anti-cancer agents during radical operation, as to decrease recurrent stomach cancer.<BR>Our method based on the laboratory data of model experiment of which results were as follows.<BR>1) When Mitomycin C was administrated into left gastric artery, we obtained the broadest infusion area in case that left gastric vein and the other gastric artery had been ligated except short gastric artries.<BR>2) Wistar rats were prevented from liver metastasis, when AH 7974 had come in contact with Mytomycin C 20μm/ml and administrated into rat spleen.<BR>3) Mitomycin C more than 80μg/ml brought side effect to male mongrel dogs. We have indicated this method to 80 clinical cases, including one patient dead postoperatively within one month; cause of death was proved to be acute cardiac failure in course of intestinal obstruction.<BR>No patient died because of chemotherapeutic complication : agranulocytosis and so on. 58 patients were treated by curative gastrectomy combined with arterial infusion. 63.6% (7/11) is 4-year survival rate of this group, while 38.9% (14/31) of control group, namely patients group treated by only curative gastrectomy.<BR>It can be seen from the above that radical gastrectomy combined with gastric arterial infusion have noticeable effect to stomach cancer.
- 北関東医学会の論文
北関東医学会 | 論文
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