STUDIES ON THE HYALINE GRANULES APPEARING IN THE LIVER OF MICE AFTER IMMUNIZATION IN EXPERIMENTAL SALMONELLOSIS:II. ENDOTOXIN HYPERSENSISTIVITY AND HYALINE GRANULES
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In experimental Salmonellosis, produced in mice with <I>S. enteritidis</I>, Mice, immunized with 10<SUP>-5</SUP>mg of an attenuated strain of <I>S. enteritidis</I> (SER), and 3 weeks threeafter reimmunized with 10<SUP>-7</SUP>mg of a virulent strain of this bacillus, achieved high grade immunity and survived the challenge of 1, 000MLD of the virulent strain.<BR>On the other hand immunized mice acquired hypersensitivity against the endotoxin of <I>S.enterisidis</I> and showed marked hyaline granules in the liver cells accompanied by severe damage.<BR>In the previous papers, we reported the experimental condition of the appearance of hyaline granules and histochemical characters.<BR>In this report, we performed the nonspecific immunization or repeated immunization with endotoxin and both results in hypersensitivity against the endotoxin and appearance of hyaline granules.<BR>Mice immunized with living vaccine of <I>S. enteritidis</I> showed anaphylactic shock against the endotoxin of <I>E. coli</I> which had no common antigens with <I>S. enteritidis</I> and died with in 24 hours accompanied by marked hyaline granules.<BR>In the other group, imumnization was done by repeated subcutaneous and intraperitoneal injection of the endotoxin of <I>S. enteritidis</I> amounting to 0.15mg in total with in 25 days. Anaphylactic shock was induced by the same endotoxin injection given after the interval of 10 days and appearance of hyaine granules was conspicuous.<BR>It is considered that hypersensitivity against the endotoxin nonspecific with regard to the O-antigen and immunization with the living vaccine of <I>S. enteritidis</I> induced antilethal resistance against the infection with the virulent strain of living vaccine but repeated immunization with endotoxins in the subcutis and the peritoneal cavity, produced hypersensitivity against the same endotoxin accompanied by marked hyaline granules.<BR>It seemed interesting to us that interrelation was found between the hypersensitivity and appearance of hyaline granules.
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