STUDIES ON ADRENAL ENUCLEATION:7. The Urinary 17-Ketosteroids Excretion with Reference to the Secretory Ability of the Regenerating Cortex of the rat

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Adult Wistar rats (150-200g) were subjected to the experiment. Left adrenalectomy f ollowed by enucleation of the right gland (AE) was performed under ether anaesthesiaand the urinary 17-ketosteroids per 24 hours (17-KS) was determined. The influence of bilateraladrenalectomy was also investigated for comparison. (1) 17-KS value in agreement with the results of bilateral adrenalectomy was very low at the 4th day after AE. (2) This low value was followed by a rapid recovery and the normal value was restored at 10 days or so after AE. (3) There was difference in the reactivity of 17-KS concentration against the exogenic ACTH between earlier (4 to 10 postoperative days) and latter (50 to 60 postoperative days) stages of regeneration. In the former stage 17-KS concentration was not aff ected by the administered ACTH, while in case of the latter it was elevated, especially at the last day of this stage to significantly high level. (4) The recovery of 17-KS after AE was suppressed by the administration of DOCA and cortisol. From the results of the present experiments, the socalled zonal theory was discussed.
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