A Histological Study of Cell Proliferation and Apoptosis in Oral Lichen Planus

概要

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Oral Lichen planus (OLP) is a chronic inflammatory mucocutaneous disease in which basal epithelial cells are damaged. It is generally known that the epithelial damage of OLP occurs due to direct infiltration of killer T-lymphocytes. However, there is a hypothesis that loss of basal cells in OLP is due to apoptosis. There are few reports about the relationship between apoptosis and OLP. The purpose of this study was to investigate the distribution of cell proliferation and apoptosis on the epithelium of OLP. Fifty-one OLP and 12 normal mucosa were evaluated for proliferation cell nuclear antigen (PCNA), apoptosis-related proteins, Fas and Bcl-2, immunohistchemically. Further, sections were evaluated with a TUNEL assay that identify apoptotic DNA fragments. Epithelial cells in normal oral mucosa and OLP mucosa were negative for bcl-2. Fas expressed in the granular and prickle cell layers in OLP epithelium. The positive signs of TUNEL assay appeared to be scatter in the basal cells of OLP mucosa, whereas there were no signs in the same area of normal epithelium. These results suggested that the basal cell destruction with apoptosis occurred in OLP.
日本口腔内科学会の論文