Difference in Expression of Bullous Pemphigoid Antigen (BPAG I, BPAG II) between Normal Oral Mucosa and Skin

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Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by the presence of circulating autoantibodies specific for hemidesmosomal proteins; BPAG I (230kD protein) and BPAG II (180kD protein). In order to explain why oral lesions are seldom seen in BP patients, the distribution of BPAG I and BPAG II in oral mucosa and skin was investigated. [Methods] Normal oral mucosa (gingiva, buccal mucosa, tongue dorsal mucosa n=3) and skin (n=3) were obtained during surgery, and cryosections were prepared. First antibodies were rabbit polyclonal antibodies against synthetic peptides of P1-1, P1-2 and NC16a. [Results] There were no differences in the staining pattern of BPAG I between oral mucosa and skin. All layers except the keratinized layer were stained by anti-BPAG II antibody in skin. However, positive staining was observed only of the basal cells in buccal mucosa and no staining in the tongue and gingiva showing a significant difference in the expression pattern of BPAG II between oral mucosa and skin.
日本口腔内科学会の論文