Effects of rapid intravenous infusion of a 7.0% sodium bicarbonate solution on arterial blood gases of heifers.
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概要
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The effects of maximum rate, 200ml/min, intravenous drip infusion (iv) of 2l of a 7.0% sodium bicarbonate solution (SBS) on alkalization of arterial pH and partial pressure of blood gas were examined at large animal practice. Six Holstein heifers, with the average body weight of 446.4±92.3kg, were subjected to 2l iv of SBS to right jugular vein at rapid (200ml/min, 10 min per administration, n=3) ormoderate (66.6ml/min, 30min, n=3) rate. From the start of iv (t=0) up to t=30min, blood samples were drawn from right femoral artery, every three minutes. Afterwards, another samples were drawn at t=120 min and t=240 min following the start of iv and all the drawn samples were subjected to blood gas analysis. Arterial blood pH's immediately before the end of iv were 7.626±0.044 (+0.195 from previous value) and 7.562±0.046 (+0.149) for rapid rate group and moderate rate group respectively, Both were significantly increased with maximum values. The maximum value was significantly higher (p<0.05) in rapid rate group;however no difference was observed between two groups at measurements from t=120 min and t=240 min. Both HCO<SUB>3</SUB> concentration and base excess have shown significant change that resulted in maximum values of each, immediately before the end of iv. However, no difference in the level of change was identified in two groups; therfore, it is suggested that the difference in the rate of administration has no effect in bioavailability. These results have shown that SBS can be administered intravenously to normal heifers at practically rapid rate and blood alkalization was demonstrated without causing any clinical abnormality. Thus, we suggest that SBS can be intravenously administered to heifers at a rate of 200ml/min.
- 日本家畜臨床学会の論文
日本家畜臨床学会 | 論文
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