Studies on the pathogenesis of bovine hyena disease.

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The following studies were carried out to clarify the relationship between the outbreak of hyena disease and the administration of vitamin AD3E (V-A D3E) premix. (1) In the examination of clinical cases, presence and dosage of V-AD3E premix were surveyed in 11 cattle aged 12 to 17 months and diagnosed as hyena disease. As the results, all of them were found to be administered excessive amount of V-AD3E premix within 1 month after birth. The bone morphometric analysis in 2 cases showed the decreased bone formation due to low turnover in bone metabolism. (2) Based on the results of clinical studies, the excessive amount of V-AD3E premix, vitamin A (V-A), or vitamin D3 (V-D3) was experimentally administered in calves to cause the outbreak of hyena disease. Each vitamin compound was daily administered to calves aged 7 days after birth for 10 days. The hyena disease was recognized in 2 out of 2 calves administered a high dose of V-AD3E premix (V-A 3, 000, 000, V-D3 300, 000, and V-E 1, 200 LU./day), 1 out of 2 calves administered a half dose of the V-AD3E premix as above described, and 1 out of 2 calves administered with only V-A (V-A 3, 000, 000 I. U./day). Two calves administered only V-D3 (V-D3 300, 000 I. U./day) did not develop the hyena disease. In all hyena disease calves, the plasma retinylpalmitate level remained high until 1 month after birth. The bone metabolism was in the state of low turnover at 50 days after birth and the bone volume was small at 12 months after birth. All hyena calves showed the flat chondrocytes, the decrease in chondrocytes, and the irregular structure of column in the epiphysial growth plate. (1) In conclusion, the excessive administration of V-A to calves resulted in the hyena disease, which attributed the cause of this disease to V-A.
日本家畜臨床学会の論文

Studies on the pathogenesis of bovine hyena disease.

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日本家畜臨床学会 | 論文

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