Effect of adriamycin entrapped in liposomes on ovarian carcinoma cells.
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概要
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Adriamycin entrapped in small unilamellar vesicles (SUV-ADM) and that in multilamellar vesicles (MLV-ADM), composed of egg yolk phosphatidylcholine, cholesterol, and sulfatide in a molar ratio of 5:4:1, were examined for their effects on ovarian carcinoma AMOC-1 cells in comparison with free adriamycin. Cellular uptake and cytotoxicity were demonstrated for both SUV-ADM and MLV-ADM. The degrees of cellular uptake and cytotoxicity of SUV-ADM were comparable with those of free adriamycin, though those of MLV-ADM were somewhat lower than those of the free or SUV-entrapped drug. From these results and previous data obtained by pharmacokinetic study, the liposomes with the above composition are considered to be useful drug carriers for chemotherapy of ovarian tumors.
- 日本酸化ストレス学会の論文
日本酸化ストレス学会 | 論文
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