Influence of Renal Artery Ligation on the Contralateral Kidney and Life Span of Rats.
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We examined the life span and blood biochemical data of Sprague-Dawley rats after left renal artery ligation (RAL). The survival rate of rats with a single kidney was 50% at the 66th week, 50% survival of control (sham-operated) rats was at the 92nd week. The RAL group showed an average life span of 68 weeks, as compared with 96 weeks for the control rats. When the RAL group was divided into three subgroups depending on the life span, we found that the body weight in the subgroup with the shortest life span was increased significantly for 25 weeks after the operation, whereas that in the subgroup with the longest life span increased more slowly. Moreover, even 10 weeks before death, the body weight in the subgroup with the shortest life span was found to be heavier than that in either of the other two subgroups. The blood urea nitrogen and creatinine levels already showed high values in the RAL group by the 4th week after the operation, and they were more than two-fold the values in the control rats by the 48th week. These results suggest that unilateral ligation of the renal artery causes abnormal metabolism of proteins and anemia due to malfunction of the remaining kidney and may be a factor in shortening the life span.
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