Effect of Eugenol on Gastric Function in Rats.
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概要
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Eugenol, an active principle of clove, is an effective secretagogue in rats, causing dose-dependent augmentation of gastric secretion. Eugenol, when administered intragastrically at 100μg/kg body weight, stimulated maximum secretion of gastric free acid and serum pepsinogen. However, at higher concentrations it had an inhibitory effect on gastric secretion. Long-term oral treatment with eugenol at a dose of 100μg/kg body weight per day for three weeks significantly increased the serum pepsinogen levels, which positively correlated with gastric free acid secretion. The levels of serum mucoprotein and α-antitrypsin remained unchanged. Histopathological examination of the stomach of experimental animals did not show any damage to mucosal cells. Thus, stimulation of gastric secretion at a low concentration of eugenol, i. e., 100μg/kg body weight and below, should facilitate digestion.
- 日本酸化ストレス学会の論文
日本酸化ストレス学会 | 論文
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