Results of Combined Lasersurgery and Irradiation in Cases of Stage I and Stage II Larynageal Cancer.

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We reviewed 97 patients with stage I and stage II laryngeal cancer who had undergone a combined therapy involving lasersurgery (CO<SUB>2</SUB> or KTP laser) and irradiation (LINAC, 2 Gy/fr/day, total 60-66 Gy) from 1988 to 1997. These patients included 88 with glottic cancer (T1a : 36, T1b : 20, T2 : 32), eight with supraglottic cancer (T1 : 3, T2 : 5) and one with subglottic cancer (T1) . The overall five-year survival rate was 82.8%, and the cause-specific-survival rate was 98.1%. The overall preservation rate of the larynx with the Kaplan-Meier method was 81.8% (stage I : 90.0% and stage II : 67.3%) . The preservation rates by subtypes were 95.5%, 80.4%, 71.6% and 58.3% for the glottic T1a, glottic T1b, glottic T2 and supraglottic types, respectively.<BR>A post-operative estimation of phonatory functions under maximum phonation time (MPT) revealed that four out of 33 patients showed extremely poor functions (MPT < 6 s) . Two of these cases were caused by iatrogenic laryngeal webs on the anterior commissure. As a result, we concluded that the combined therapy in the present study was satisfactory for stage I and stage II laryngeal cancer except in cases of supraglottic cancer, cases with masses on the anterior commissure or cases with carcinoma in situ.
特定非営利活動法人日本気管食道科学会の論文