Clinical Studies of Beclomethasone Dipropionate Inhaler (Aldecin) on Granulomas of the Larynx.

概要

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Non-specific granulomas of the larynx are relatively rare inflammatory tumors. Voice therapy is the most efficacious means of dealing with these tumors. However, surgical removal has been performed frequently for this disorder. At the Keio University Hospital, 79 cases of granuloma have been surgically treated from 1965 to 1986. Such tumors have a great tendency to recur. The recurrence rate in our study was 47.1%.Beclomethasone dipropionate inhaler (Aldecin®) were used to treat 49 cases of nonspecific granuloma of the larynx from 1987 to 1991. Aldecin® was administered by oral spray in two, 50 microgram-per-puff doses, four times daily yielding a total daily dose of 400 micrograms taken over one to fourteen months. In this trial, symptoms and findings improved markedly over the course of six months in 31 cases (63.3%). Two cases of candidiasis of the pharynx as a side effect were noted. We believe that proper voice therapy, or long-term resting of the voice, can be a very important factor in the cure of this disease, but that it may be impractical. In these cases, and as a initial treatment, Aldecin® is a very usuful therapeutic adjunct for the treatment of non-specific granulomas of the larynx.
特定非営利活動法人日本気管食道科学会の論文