A study on protease in tracheobronchial secretion. 7. Effect of nebulization of Miraclid on fibrinolytic activity in tracheobronchial secretion of rat.:7. Effect of Nebulization of Miraclid on Fibrinolytic Activity in Tracheobronchial Secretion of Rat
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It has been reported that plasminogen activator existed in tracheobronchial secretion of rats. From the results of previous studies, it was expected that inhibition of proteolytic enzyme in tracheobronchial secretion conducted to control the process of inflammation in the respiratory tract. In this study, Miraclid, a polyvalent inhibitor derived from human urine was used in this experiment of in vitro and nebulization of rats. Furthermore, the effect of Miraclid nebulization on fibrinolytic activity was studied in tracheobronchial secretion of rats. From the result of in vitro study, it was clarified that Miraclid could inhibit caseinolytic activity of trypsin, and fibrinolytic activity of urokinase and papain. However, it was clarified that Miraclid could not inhibit caseinolytic activity of papain. On the other hand, from the results of animal experiment, it was clarified that fibrinolytic activity in tracheobronchial secretion of rats decreased in administration group in comparison to non-administration group after administration of Miraclid through nebulizer. From the above-mentioned results, it was suggested that nebulization of Miraclid might be useful to control the inflammation in the respiratory tract.
- 特定非営利活動法人 日本気管食道科学会の論文
特定非営利活動法人 日本気管食道科学会 | 論文
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