Clinical Investigation on New Anticholinergic Bronchodilator in Bronchial Asthma
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The new anticholinergic compound Sch 1, 000 (ipratropium bromide) has been reported to be an effective bronchodilator without significant atropine-like side effects.We evaluated the effectiveness of nebulized Sch 1, 000 in 30 patients with bronchial asthma. Pulmonary function was determined before and after Sch 1, 000 administration and aerosolized methacholine (3μg/dl) or causal allergic antigen inhalation.Sch 1, 000 was effected to slight and moderate asthma attack. However, the effectiveness of inhibition to asthma attack was not so strong than the action of broncho-dilator by β-stimulants.The protective effects of Sch 1, 000 on methacholine induced bronchoconstriction and allergen induced asthma were clearly observed.These results suggest that Sch 1, 000 has not stronge effect than β-adrenergic agonicts has, while the protevtive effects to methacholine and allergen induced bronchoconstriction are distinguished.
- 特定非営利活動法人 日本気管食道科学会の論文
特定非営利活動法人 日本気管食道科学会 | 論文
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