Immunological Aspects
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概要
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For the purpose of elucidating relationship between the upper and lower respiratory tracts, the present work was performed from immunogical point of view.1) The immunological function of the tonsil was investigated on separated tonsillar cells by using in-vitro culture system. As a result, it was revealed that the tonsil was composed of three cellular components (T cell, B cell and macrophage) necessary for the immune response and cellular co-operation among them was required for the effective immune response to a hapten-carrier antigen.2) To elucidate experimentally some characteristics of the immune response against inhaled antigens, guinea pigs were exposed to an aerosolized hapten-protein antigen. Specific anti-hapten antibody forming cells were determined by PFC (plaque-forming cell) assay.When the antigen was given via respiratory tract by inhalation, the antibody production was much more predominant in the paratracheal and peribronchial lymphnodes than in the spleen -a distant lymphoid organ. On the contrary, when the antigen was given by subcutaneous injection, a reverse result was obtained.This suggests a possibility that the immune response to air-borne antigens may be carried-out selectively and locally in the lymphoid tissues in the vicinity of the respiratory tract.3) Our clinical studies on 700 patients with pollinosis revealed that 67.7 percent of the patients had nasal symptoms without any bronchial symptom, while only 11.6 percent had bronchial symptom without any nasal symptom.This result suggests that alllergic reactions in the respiratory tract initially takes place in the nose, i. e, the upper respiratory tract in general, which may protect the lower repiratory tract from external antigen.
- 特定非営利活動法人 日本気管食道科学会の論文
特定非営利活動法人 日本気管食道科学会 | 論文
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