An Involvement of the Wall of the Air Way in Experimental Tuberculosis of the Hilar Lymph Nodes
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In order to inquire into the attack on the wall of the air way directly from the hilar lymph nodes infected with tubercle bacilli and its relation with the changes in the lungs, the author investigated pathohistology of 447 hilar lymph nodes removed from 78 cavies.<BR>Experiments on the primary infection were divided into 4 groups; 0.025 mg. of germs in group 1 and 0.01 mg. of such in group 2 suspended in distilled water were infused into the tracheas, and 0.001 mg. of germs in distilled water in group 3 and 0.001 mg. of such in a mixture of liquid paraffin and dehydrated lanolin in group 4 were injected into the lungs.<BR>Periods of inoculation were arranged from two days to 52 weeks.<BR>In experiments on superinfection, those with 0.001 mg. of germs in a mixture of liquid paraffin and deydrated lanolin injected into the lungs as the primary infection, were divided into 4 groups at the 21st week.<BR>And as superinfection, 0.001 mg. in group 5 and 0.5 mg. in group 6 suspended in distilled water were infused into the tracheas, and 0.001 mg. in group 7 and 0.5 mg. in group 8 in a mixture of liquid paraffin and dehydrated lanolin were injected into the lungs.<BR>Periods of inoculation were arranged from 1 to 8 weeks.<BR>In all but group 2, experimentations were executed under general narcosis.<BR>In group 1 alone, autopsies were held after the natural death.<BR>The strain of the employed tubercle bacilli was all H37RV.<BR>The following conclusions were drawn from the experiments mentioned above.<BR>1. Changes of the hilar lymph nodes were noticed in all the animals.<BR>In 39.7 % of them there were no changes in the lungs but development of changes of the lymph nodes themselves and involvement of the walls of the airway.<BR>This gave some probability to Schwartz's assertion.<BR>2. Those with changes in the lungs had nearly twice as many caseous lymph nodes as those without such changes had.<BR>3. In cases with caseous lymph nodes, the incidence of perforation was about 17 times and that of overall involvement about 2 times more than in the cases with noncaseous lymph nodes.<BR>4. In experiments on the primary infection, changes in the lungs, those of the lymph nodes and the incidence of involvement differed remarkably by the experimental factors such as the quantity of the germs, the method and period of inoculation.<BR>Influences of superinfection were seen to some degree in the pulmonary lesions, but neither in changes of the lymph nodes nor in involvement of the wall of the airway.<BR>5. In all the experiments, microscopic perforations were noticed in 1.2% of the cases, the overall incidence of perforation amounted to 19.2%, that of involvement to 82%, and in 1.5% the perforations were associated with fistulae and ulcers in the mucons membrane of the air way.
- 特定非営利活動法人 日本気管食道科学会の論文
特定非営利活動法人 日本気管食道科学会 | 論文
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