Effect of Bed Rest on the Intestinal Environment and Microflora in Healthy Young Men
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概要
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To clarify the change in intestinal microflora under a microgravity environment, we chose 12 health young men (22.2±3.2 years old) for a 20-day bed-rest experiment. After a 4-day adjustment period, the subjects were put to bed in a head-down position at an angle of 6°. The basic food intake was provided by a menu cycle of 4 days to maintain the body weight which contained 1, 931kcal of energy, 67g of protein (14% PE), 53g of fat (24% FE) and 291g of carbohydrate (62% CE).A comparison between the data for the experimental period of two weeks and the adjustment period shows that the number of Lactobacilli decreased by a significant level (p<0.05) and the number of Clostridium perfringens increased by a significant level (p<0.05) in the feces, while no change was apparent for the other bacteria.The results also demonstrate that, among the putrefactive substances (phenol, p-cresol, ethyl-phenol, indole and skatole) in the feces, p-cresol increased by a significant level (p<0.05) and phenol tended to decrease. A evaluation of the mental status by the Zung self-rating depression scale (SDS) indicated the onset of depression during the test period due to the lack of activity.These results suggest that the deterioration of the intestinal environment from the change in intestinal bacteria and the increase in putrefactive substances was caused by long-term stress induced by 20 days of bed rest under the microgravity environment.
- 特定非営利活動法人 日本栄養改善学会の論文
特定非営利活動法人 日本栄養改善学会 | 論文
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