:Part 3. Effect of Sucrose Diet on Serum High Density Lipoprotein Cholesterol, Fecal Excretion of Neutral Sterols in the Cholesterol-fed Rats

概要

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The purpose of this study was to elucidate the effect of dietary sucrose on serum high density lipoprotein (HDL) cholesterol levels and fecal excretion of neutral sterols in cholesterolfed rats. The animals (male, Sprague-Dawley) were fed a diet containing 0.5% cholesterol and 0.25% sodium cholate with sucrose or corn-starch for 10 days. The replacement of dietary starch with sucrose significantly increased the serum total cholesterol concentration in cholesterol-fed rats. The reduction of cholesterol content in serum HDL was observed in the rats placed on the sucrose diet. Consequently, atherogenic index (LDL-chl+VLDL-chl/HDL-chl) was higher in the sucrose fed rats than in the starch fed ones. The sucrose diet reduced the total dry weight of feces excreted during 10 days. Fecal excretion of cholesterol showed progressive increase in both groups. However, the animals fed the sucrose diet showed consistently lower cholesterol values in feces than these fed the starch diet. The apparent excretion rate of cholesterol fell in the rats of the sucrose diet. The addition of cholesterol with cholate to the diets drastically reduced the fecal output of coprostanol, microbial product of cholesterol, in both carbohydrate groups. These findings suggested that dietary sucrose enhanced the absorption of external cholesterol more than dietary starch did.
特定非営利活動法人日本栄養改善学会の論文