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The present study was undertaken to clarify the interaction between PCB toxicity and dietary protein.Weanling male rats of the Sprague-Dawley strain received experimental diets containing 0.1% PCB. The PCB used was a mixture of isomers, of which tetrachloride was dominant.When the rats were given the 0.1% PCB diets with different levels of casein for 55 days, a slight gain of body weight was observed in the 10% casein group. The growth rates in the 20% and 30% casein groups were almost similar to that of the 10% casein group without PCB, the two groups showing no difference in growth rate.When the rats were given the 0.1% PCB diets with different kinds of protein sources at 20% level for 6 weeks, it was shown that the growth rate was largest in the soy-protein group, followed in this order by the casein, egg-protein and gluten groups. The reason for the low growth rate in the egg-protein-PCB group was explained at both points of lipotropic action and mixed function oxidase induction by the surplus of sulphur-containing amino acids unnecessary for the decreased growth by PCB administration.Liver weight per 100g body weight in the PCB group was found to be decreased by the high level of dietary protein. However, the phospholipid concentration in the serum of rats given 0.1% PCB increased significantly regardless of the level and quality of dietary protein.
特定非営利活動法人日本栄養改善学会の論文