Effects of Calcium on the Physical Development and Toxic Symptoms in Rats Poisoned with Lead

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Studies were conducted to clarify the effect of calcium on the development and toxic symptoms in rats poisoned with lead, and following experiments were carried out.Male Sprague Dawley rats, weighing about 50g, were divided into two groups; the lead-administered group and the control group. Distilled water was given to the control group and lead solution containing 1, 500ppm of lead nitrate was administered to the lead-administered group for 3 weeks. Each group was sub-divided into four groups; normal calcium (Ca/P=1.5) and 13% albumin group; low calcium (Ca/P=0.25) and 13% albumin group; normal calcium and 4% albumin group; and low calcium and 4% albumin group.The food efficiency of 13% albumin group was higher than that of 4% albumin group, and that of normal calcium group was higher than that of low calcium group. The amount of lead in blood of normal calcium group was lower than that of the low calcium group. Amount of lead in liver showed a same tendency. Number of red blood cells, amount of hemoglobin, and hematocrit value in the low calcium group were less than those in the normal calcium group.From these findings, it is concluded that the intake of low calcium diet enchanced the lead poisoning.
特定非営利活動法人日本栄養改善学会の論文