:PCB Toxicity and Nutrition (IX)
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概要
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In the present study, the interaction between PCB toxicity and dietary fats was examined. Weanling male rats of the Sprague Dawley strain received the experimental diets containing 0.1% PCB which tetrachloride isomer was dominant.When rats were fed the 0.1% PCB diets containing different kinds of fats at 10% levels for 6 weeks, it was found that the growth rate of lard group was significantly lower than that of the other three groups; soybean oil, olive oil, and crisco. Although the experiment was repeated, the result was entirely same.It was also shown that the weight gains of experimetal animals given 0.1% PCB for 6 weeks were varied by the different levels of fats which were kept to 5% and 25% in the diet. The growth rates of 5% soybean oil group and 5% lard group were lower than that of 25% fat groups. Especially, the weight gain of 5% lard group was the lowest and only four of 9 rats in this group survived over 38 days after PCB treaments started.The significant increase of phospholipids and cholesterol concentration in the serum and liver of rats given 0.1% PCB was shown regardless of the quality and level of dietary fats. On the other hand, triglyceride concentration in the serum and liver of the PCB-fed group was tended to decrease, but it was rather tended to increase in the liver of rats fed a 0.1% PCB diet with 25% level of soybean oil.It was found that unmetabolized PCB was much more accumulated in the liver of 25% fat groups than that of 5% fat groups.Finally, the possible mechanism on severe toxic effect of PCB in the low lard group was discussed in connection with the relative increase of linoleic acid requirement followed by the elevation of phospholipids in the animals given PCB.
- 特定非営利活動法人 日本栄養改善学会の論文
特定非営利活動法人 日本栄養改善学会 | 論文
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