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The Wister strain male rats 3 weeks of age were fed the folic acid deficient diet containing sulfanilamide for 2 months. Then, the effect of folic acid deficiency on their avoidance learning behavior was studied. In order to obtain some evidence about the cause of their behavioral change, brain and adrenals were analyzed for tyrosine hydroxylase, tryptophan-5-hydroxylase and catecholamine content.Although, the leucocytes counts, granulocytes counts and hemoglobin concentration of the folic acid deficient animals were less than those of the control group, their erythrocytes counts showed only a slight decrease. These findings suggested that they were suffered from rather moderate folic acid deficiency. The avoidance learning behavior of the deficient group showed the poor ability to avoid electric shock even after 90 trials and there was a significant difference in the rate of learning between this group and the control group. However, the brain norepinephrin content and the activities of tyrosine hydroxylase and tryptophan-5-hydroxylase of the deficient group were not different from those of the control group. These results suggested that the change in learning behavior due to folic acid deficiency would not be caused at least by the defects of the brain catecholamine metabolism. While, adrenal tyrosine hydroxylase activity was elevated significantly in the deficient group without an increase of the adrenal weight. The similar results were obtained in the animals suffered from aminopterine induced folic acid deficiency. The enhancement of the enzyme activity seemed to be attributed to the change of catecholamine metabolism of the adrenal medulla which might be caused by the abnormal activity of central sympathetic nervous system in the folic acid deficient animal.
- 特定非営利活動法人 日本栄養改善学会の論文
特定非営利活動法人 日本栄養改善学会 | 論文
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