:(2) Influence of Lysine Supplementation to the Gluten Diet on Distribution of 14C-Threonine and 3H-Leucine in Several Tissues

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Lysine supplementation to the gluten diet is known to be accompanied by a significant drop in the plasma free threonine concentration of the rat. This study was conducted to determine the cause of its phenomenon. The results obtained follows;1. Two groups of four young rats were fed for four weeks the 20% gluten diet supplemented with or without 5% L-lysine·HCl. Weight gain of lysine supplement group was three times higher than that of non-supplement group. Free threonine concentrations in serum, muscle, liver, and small intestine were significant lowered when the gluten diet was supplemented with lysine. But most other amino acid concentrations in serum and tissues showed no marked changes.2. Ratios of acid soluble radioactivity to protein radioactivity from 14C-threonine and 3H-leucine injected intraperitoneally decreased in muscle, liver and small intestine of rats on a diet supplemented with lysine. These ratios for 14C-radioactivity (except 3H-radioactivity) in muscles of either supplemented or non-supplemented rats were significantly higher than that in other tissues.3. The results suggest that the marked decline of free threonine levels in serum and tissues caused by feeding lysine supplement gluten diet may be due to increased incorporation of threonine into protein of muscle and any other organs, and accerelated transport of threonine from organs to muscle.
特定非営利活動法人日本栄養改善学会の論文