Observation on development of tumors in the livers of mice by diet containing Luteoskyrin (Toxic Pigment of P. islandicum Sopp)
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Mice were fed for different periods on a high-protein or low-protein diet with or without luteoskyrin added at a concentration of 5mg per cent. The growth, mortality, weight of the liver, and histopathological changes of the liver of the animals were examined.Nodular hyperplasia of the liver cells were noted in some of the test animals which had been fed on the low-protein diet with luteoskyrin for 90 days. The feeding was continued for additional 90 days, then approximately 50% of the survived mice were found to have developed nodular hyperplastic proliferation of the liver cells.No development of nodular hyperplasia of the liver cells was observed in the groups of the test animals fed on either only basal diet or high-protein diet with luteoskyrin during the test period.These observations suggest that the metabolic function of the liver cells may be affected by the feeding on the low-protein diet resulting in induction of an abnormal state as described by Berman. Consequently hyperplastic proliferation of the liver cells were induced in the animals by the supplementation of luteoskyrin to the low-protein diet.
- 特定非営利活動法人 日本栄養改善学会の論文
特定非営利活動法人 日本栄養改善学会 | 論文
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