Application of Controlled Rate Thermogravimetry(CRTG) to Water-content Determination in Drugs.
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概要
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In order to improve the quantitative separation of water-content consists in residual water and crystal water in drugs, controlled rate thermogravimetry (CRTG) was applied to determination of dehydration.The water-content data estimated on the basis of weight loss profile determined by the CRTG, were compared with weight loss values obtained with TG of linear heating rate. Simultaneous Thermogravimetry-Mass spactrometry (TG-MS) was also utilized for identification of chemical speices to confirm if their volatile contaminant is only water or major volatile constitute is water. The results suggest that the CRTG method can be applied to the determination of water-content in drugs, and that the CRTG is especially very effective technique as a substitute for the loss of drying (LOD) test on the Pharmacopoeia of Japan.
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