Anesthesia and its thermal analysis.

概要

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Because of the structural diversity, it is thought that the general anesthetics act nonspecifically to alter the physico-chemical properties of the cell membrane, rather than to stimulate the process taking place via specific receptors. It was indicated in Meyer-Overton theory that the relative potency of the anesthetics was closely related to the solubility of the drug in oil and that the biophysical events are fundamental to exert the anesthetic action. Subsequently, the other mechanisms of anesthesia based on the biophysical standpoint have been proposed. At the present time, it is well recognized that the interaction between anesthetics and the phospholipid bilayers of the cell membranes may cause the alteration of physical properties of the membrane which is essential to induce anesthesia. The thermal analysis, performed by means of differential scanning calorimetry (DSC), made an important contribution to elucidate the mechanism of interaction between anesthetic molecules and phospholipid bilayers. In this review, the historical background and the application of DSC for the analysis of anesthetic action are discussed.
日本熱測定学会の論文