Changes in mucociliary function and tissue oxygen tension in dogs following sleeve lobectomy.

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To determine the effect of sleeve lobectomy on mucociliary function and bronchial circula-tion, we evaluated the recovery of mucociliary transport (MCT) and tissue oxygen tension (PtO2) in 12 dogs after right cranial sleeve lobectomy. Six of the dogs also had thoracic vagotomy. The postoperative MCT of the operated bronchus was significantly below the preoperative MCT on the seventh postoperative day (7 POD) and 14 POD. It increased to the preoperative level on 21 POD. On the other hand, the MCT of the left bronchus was unchanged during the postoperative course. No significant differences in the MCT were noticed between those with and those without vagotomy. The ratio of right to left PtO2 during the postoperative course varied with the MCT. A significant correlation between the ratio of right to left MCT and that of PtO2 was observed. A light microscopic study showed that the mucosal recovery was almost complete, but a scanning electron microscopic (SEM) study revealed an incomplete structural recovery of the bronchial mucosa on 21 POD. These results indicated that the MCT was impaired following sleeve lobectomy and recovered with the PtO2, although SEM showed that histologic recovery of the bronchial mucosa was not complete on 21 POD. It was found that thoracic vagotomy did not influence MCT.
特定非営利活動法人日本呼吸器外科学会の論文