Surgical Treatment of Brain Metastasis and Lung Cancer

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Both primary lung cancers and associated brain metastases were resected in ten patients : four males and six females aged 44 to 66 years (mean, 51.7 years). Eight patients had solitary and two had multiple brain metastases. Histologically, eight patients had adenocarcinomas and two had large cell carcinomas. After resection of the brain metastasis, eight patients received radiotherapy and/or chemotherapy. There were no operative or hospital deaths. Survival after craniotomy was 6 to 37 months (median, 10 months). Survival at one year was 40%. Only one patient is still alive. Four patients died of systemic metastases, two of intracranial recurrence and three of other diseases. The interval between thoracotomy and crandiotomy was 1 to 29 months (median, 11 months). The disease-free interval correlated positively with survival. After craniotomy all patients clearly had much relief from severe preoperative neurological symtoms.<BR>In conclusion, surgical resection of both primary lung cancer and brain metastasis seems to prolong survival and improve "Quality of Life" of patients, especially those with a solitary brain metastasis and a long disease-free interval.
特定非営利活動法人日本呼吸器外科学会の論文