Experimental study on canine lung transplantation

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An experimental study on canine lung transplantation was performed, comparing intra cellular enzyme activity of the peripheral lung tissue with histological findings. Before morphological damage could be recognized, enzymological cellular damage of lung tissue was demonstrated. In particular, lysosomal enzyme activity was considered to be one of primary factors associated with lung tissue injury under conditions of warm ischemia.<BR>In order to estimate the revascularization of the bronchial anastomosis and the rejection process in canine lung transplantation, we performed fluorescein assisted endoscopic bronchial imaging (FEBI) following bronchoplasty and lung auto-and allotransplantation. In cases of bronchoplasty there was no difference in the time required for complete revascularization of bronchial anastomosis between autotransplantation and dogs undergoing allotransplantation and treated with cyclosporine. Bronchial mucosal revascularization was confirmed 14 to 21 days postoperatively. In allotransplanted dogs in which rejection was later recognized the absence of fluorescein from the bronchial mucosa in sub-sub segmental bronchi after FEBI suggested damage to the vascularization in that lesion and, by extension, implicated this vascular system in the rejection phenomenon.
特定非営利活動法人日本呼吸器外科学会の論文