Circadian Rhythmicity of Heart Rates in Centenarians.
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概要
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Holter electrocardiography was used to study the circadian rhythm of heart rate in 50 centenarians living in Tokyo and in Aichi prefecture. As a control group, 50 healthy subjects aged under 65 years old underwent medical check-ups including Holter electrocardiography at Keio Health Consulting Center. Harmonic analysis was used to approximate the 24-h time-series data on the RR intervals to a summation of three cosine waves with 24-h, 12-h and 8-h periods. The power of each period was adjusted for the goodness of the curve-fit, and the powers of the centenarians were compared with those of the controls. Then all the subjects were classified by k-means cluster analysis into k groups based on the power of the period, and patterns of heart rate rhythms were then idenitified. The power of the 24-h period in centenarians (32.7±16.0%) was significantly lower than that in controls (45.8±17.8%). Although there were no signigicant differences in the powers of the 12-h and 8-h periods, the power of the 8-h period in centenarians (7.0±8.4%) was slightly higher than that in controls (4.2±3.3%). Advances or delays in acrophase (acrophasal shift) were more common in centenarians than in controls. Five patterns of heart rate rhythms were identified: 24-h period dominant (n=58). 24-h+12-h period (n=15), 12-h period dominant (n=7), 8-h period augmented (n=7), and low curve-fitting (n=13). Both the 8-h period augmented pattern and the low curvefitting pattern were more common in centenarians than in controls. Both the 24-h period dominant pattern and the 24-h+12-h period pattern were less common in centenarians than in controls. These data indicate that the circadian rhythm of heart rate changes with aging.
- 社団法人 日本老年医学会の論文