Backgrounds of the carcinoma of gallbladder and extrahepatic bile ducts.
スポンサーリンク
概要
- 論文の詳細を見る
To demonstrate correlation between occurrence of carcinoma and that of gallstone of the gallbladder and biliary tract, we reviewed the protocols of gallbladder and extrahepatic bile duct carcinoma and cholelithiasis of 4482 cases (male 2237, female 2245, mean ages 77.7 years old) autopsied at the Department of Pathology, Tokyo Metropolitan Geriatric Hospital, during 27 years from 1960 to 1986. Gallbladder carcinoma was found in 94 cases or 2.1%. The incidence was higher in the female than in the male (male 24, female 70, p<0.01). Gallstone of the gallbladder was found in 957 cases or 21.4%. In the male, the incidences of gallbladder carcinoma and stone increased with age until lower half of the nineties, whereas in the female, no such tendency was found after sixties. No significant differences were found in the incidence of gallbladder carcinomas combined with cholecystolithiasis among all age groups of both sexes. The incidence of gallbladder carcinoma was significantly higher in the cases with cholecystolithiasis than in those without stones (p<0.01). Furthermore, the incidence of gallbladder stones in the cases with stage 1 carcinoma was significantly higher than that of those without carcinoma (p<0.01). Cholesterol stones were more common than bilirubinate in the carcinoma patients (p<0.05). These results suggested the importance of cholecystolithiasis, especially that of the cholesterol stones as a background factor of gallbladder carcinoma. Extrahepatic bile duct carcinomas were 33 cases or 0.7% (male 19, female 14, no sex preference). The incidence was significantly higher in the cases with stones than in those without stones of the extrahepatic bile ducts (p<0.01). But the fact that samll stones were found in the upstream portions of obstuctions of the biliary tracts and no stones were fond at operations in the 11 operated cases suggested that the stones may be scondary to the obstruction due to cancerous growth.
- 社団法人 日本老年医学会の論文