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When the rats were kept under conditions of reduced oxygen supply, thiobarbituric acid (TBA) reactive substances in the serum, in the abdominal arterial wall and in the brain tissue showed a significant increase at two weeks. While, the liver tissue levels of TBA reactants were slightly increased, but the change was insignificant at two weeks. At four weeks of feeding under conditions of reduced oxigen supply, the serum, brain tissue and liver tissue levels of TBA reactants declined near the values obtained before onset of the experiment. But the TBA reactants in the abdominal arterial wall showed a still higher increase. These observations indicated the possibility that hypoxia might be one of the factors predisposing to the accumulation on lipid peroxide in the arterial wall.We cannot explain the increase in TBA reactive substances in conditions of hypoxia exactly, but the fact that TBA reacting substances increase in conditions of hypoxia suggests that peroxidation may occur not only in conditions of excessive supply of oxygen but also in conditions of short supply of oxygen. This phenomenon may provide an important clue to the elucidation of the causes of various clinical disorders arising from hypoxia.
社団法人日本老年医学会の論文