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Arachidonic acid (AA) and thromboxane A2 are potent aggregators of human platelets but, in contrast, eicosapentaenoic acid (EPA) and thromboxane A3 do not cause platelet aggregation.The concentrations of AA and EPA in human serum lipids were measured in relation to ageing using gasliquid chromatography.1) No significant age variation was observed in the amounts of total fatty acids in serum. However, differences in fatty acid compositions were observed between the young group and the aged group with higher percentages of saturated and monounsaturated fatty acids and with lower percentages of polyunsaturated ones in the aged.2) Serum level of AA decreased with age both in males and females, whereas the opposite change was observed in the level of EPA. Then, EPA/AA ratios were significantly higher in the aged groups than in the young one.3) The distribution of AA and EPA into triglycerides, cholesterol esters and phospholipids in serum were also studied.4) The results were discussed, especially in relation to dietary habits.
- 社団法人 日本老年医学会の論文