Experimental Study on Thermochemotherapy. III. Combination of Temperature Sensitive liposome-Encapsulated Mitomycin C and Radiofrequency Heating.:Experimental Study on Thermochemotherapy III

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Temperature sensitive liposome-encapsulated MMC (liposome MMC) was developed to increase the efficacy of thermochemotherapy. Ascitic Yoshida sarcoma cells were implanted to male Donryu rats. When tumors grew about 500 mm<SUP>3</SUP> in volume, the rats were treated with varying intravenous dosages of a liposome and native form of MMC to compare the effects between the two forms. Then, rats with tumor were treated with hyperthermia at 42°C and intravenous 0.5 mg/kg of liposome MMC or native MMC. Marked inhibition of tumor growth was observed in the growp treated by liposome MMC compared with native MMC when combined with hyperthermia. The intratumor MMC concentration was about 4.2 times higher by the area under the curve in the treatment by liposome MMC and hyperthermia than the treatment by native MMC and hyperthermia. This increase in the intratumor MMC concentration may have caused the enhancement of inhibitory effects on tumor growth. Thus, temperature sensitive liposome-encapsulated MMC is a good drug delivery form to increase the efficacy of thermochemotherapy.
日本ハイパーサーミア学会の論文