Efficacy of Thermochemotherapy on Rat Implanted Solid:Yoshida Sarcoma Histopathological Study

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The efficacy of thermochemotherapy was examined by using solid Yoshida Sarcoma implanted on the feet of rats. Water bath treatment was applied for heating. With heat treatment alone, 42-44°C induced significantly tumor growth suppression. At 45°C, the tumor size was reduced significantly. Treatment with MMC alone reduced significant tumor growth. 42°C or 43°C heating combined with 1 mg/kg MMC induced complete tumor regression which was not obtained through heating alone or chemotherapy with MMC alone.<BR>Histopathologically, central necrosis, fibrinous thrombus and obliteration of the blood vessels were observed on the 5th day after heating at 42°C and over. Severe necrotic changes such as coagulating necrosis of the deep seated striated muscle were observed with 45°C heating on the 5th day. A small number of viable tumor cells remained surrounding the necrotic lesion on the 5th day after treatment with 1 mg/kg MMC alone, however, necrotic or degenerative tumor cells with pyknosis of the nuclei were found strikingly.<BR>The histopathological findings with thermochemotherapy showed remarkable changes such as complete tumor necrosis as compared with either heating alone or MMC alone.<BR>The efficacy of thermochemotherapy was synergistic.
日本ハイパーサーミア学会の論文