Challenge of Hyperthermia Combined with Chemotherapy or Chemo-radiotherapy for Unresectable Intrathoracic Malignant Tumors: A Preliminary Result

概要

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As prognosis after radiotherapy for patients with unresectable intrathoracic tumors is still extremely poor, such patients need intensive treatment. The aim of this study is to investigate the feasibility of hyperthermia combined with chemotherapy or chemo-radiotherapy for patients with advanced intrathoracic tumors. Our treatment regimen consisted of weekly concurrent thermo-chemotherapy using a low-dose of CDDP and CPT-11 with or without definitive radiation therapy. Our study has demonstrated that 2 out of 11 tumors showed a complete response and partial response was achieved in 3 tumors as the initial effects of the treatment. Furthermore, 2 patients with advanced Pancoast tumors survived for over 2 years without any indication of recurrence. All patients underwent the complete course of treatment without evidence of grade 3 or worse non-hematological toxicity, including pneumonitis. We have therefore concluded that thermo-chemo-radiotherapy with concurrent administration of CDDP and CPT-11 at a low dose may be tolerable and effective for unresectable intrathoracic malignant tumors.
日本ハイパーサーミア学会の論文