Clinical Appraisal of Hyperthermic Treatment Combined with Low Dose of Gemcitabine Hydrochlo Ride for the Unresectable Pancreas Cancer
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概要
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<I>Background</I> : For the patients with unresectable pancreas cancer, improvement of quality of life (QOL) and prolongation of prognosis are most important proposition. The consecutive treatment with few side effects is required. For an unresectable pancreas cancer, we perform the hyperthermic therapy combined with low dose Gemcitabine Hydrochloride (GEM). In this study, we reviewed clinical significance of thermochemotherapy for unresectable pancreas cancer as tumor dormancy therapy.<BR><I>Object and a method</I> : For the 10 patients with unresectable pancreas cancer, we have performed thermochemotherapy. Hyperthermia was administerd once a week and GEM was simultaneously given during hyperthermia. The effect of thermo-chemotherapy was evaluated from tumor contraction effect, variation of tumor marker value, and clinical benefit (assessed by pain relief and Karnofsky Performance status (KPS)). The prognosis of these patients compared with the 11 patients received best supportive with unrespectable pancreas cancer (BSC group).<BR><I>Results</I> : The frequency of thermochemotherapy ranged from four sessions to 43 sessions (19.6 ± 12.1). As the antitumor effects, response rate was 10% and the decrease of a tumor marker was found in eight patients (80%). Responder in clinical benefit was recognized in six patients (60%). Median survival periods were 212 days of the patients in the TC group, and 140 days in the BSC group. The significant difference was accepted in both survival curves. Three out of 11 patients in the BSC and nine of 10 patients in the TC group could discharge from the hospital. Severe adverse reaction as grade 3 or 4 was not cncountcrcd.<BR><I>Summary</I> : The hyperthermic treatment combined with low dose GEM for the patients with unresectable pancreas cancer could be continued for a long term under the favor of few harmful toxicity, and which should bring about the favorable clinical benefit and the improvement of prognosis.
- 日本ハイパーサーミア学会の論文
日本ハイパーサーミア学会 | 論文
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