Heat Shock Proteins: Chaperoning of Innate and Adaptive Immunities
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概要
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Recent evidence is accumulating for the important role of heat shock proteins in initiating innate immune responses, i. e., activation of antigen-presenting cells, such as dendritic cells and macrophages. Therefore, immunization with a heat shock protein-peptide complex isolated from cancer cells or virus-infected cells has been shown to elicit a protective anti-tumor or antiviral cellular immune response without additional adjuvants. Furthermore, CD91 (α2-macroglobulin receptor) and scavenger receptor LOX-l were proposed to serve as the unique receptors responsible for the receptor-mediated endocytosis for Hsps. In this review, we discuss the primordial property of heat shock proteins in innate immunity and the symphonic linkage of adaptive immunity and its implications for hyperthermic cancer therapy.
- 日本ハイパーサーミア学会の論文
日本ハイパーサーミア学会 | 論文
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