Ten Cases of Advanced Uterine Cervical Carcinoma Treated by Radiohyperthermia and Followed over Five Years.

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The treatment of locally or regionally advanced carcinoma of the uterine cervix is still controversial. We present here ten advanced primary cases of uterine cervical squamous carcinomas treated between 1991 to 1992. The pelvic doses were 54.7 ± 3.8 Gy externally and 25.7 ± 2.7 Gy (point A) intracavitary. Hyperthermia (HT) was performed using a Thermotron RF8, and the effective heating times (>41 °C) was 202.4± 44.0 min / 6.6± 0.8 sessions. The mean over-all treatment period was 59.4 ± 8.8 days. Acute adverse effects were observed in two patients, including umbilical burning and a subcutaneous consolidation cranial to the pubic bone. All the stage III patients (N = 7) were locally controlled during their follow-up period. The overall 5-year survival rates for stages III and IVa (N = 3) were 50% and 33%, respectively. The later results were relatively good in patients who did not develop hematogenous metastasis.<BR>The treatment administered was effective for the local control of stage III disease, but not for systemic control. Therefore, a new protocol for radio-chemo-hyperthermia is necessary for improving the survival rates.
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