Whole Body Mild Hyperthermia by Near-Infrared Rays.
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概要
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We had previously performed whole body hyperthermia (WBH) by extracorporeal farinfrared irradiation (Robins et al. : J. Cancer Res, 45 : 3937-3944, 1985.), which is less invasive than WBH by the extracorporeal blood warming method (Parks et al. : J. Cardiovasc. Surg, 78 : 883-892, 1979.), in patients with advanced cancer. WBH has been performed at 41.8°C for 60-90 minutes, but the effectiveness of long-term hyperthermia at a physiologic temperature of about 40-41°C (mild hyperthermia) has recently attracted attention. We have also been interested in this approach and have evaluated the optimal method for this treatment. In this study, we compared WBH induced by far-infrared irradiation, which we have routinely performed, and WBH induced by near-infrared irradiation. As a result, the dose of the anesthetic needed was reduced to 1/2-1/3, and stress to the cardiovascular system was mitigated, by near-infrared irradiation compared with far-infrared irradiation. Near-infrared irradiation is expected to play an important role as a method to induce mild WBH in the establishment of this therapy.
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