Clinical Experiences of Intracavitary Hyperthermo-radiotherapy. Analysis of Treatment Results and Adverse Reactions.
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概要
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Purpose : We have applied intracavitary hyperthermo-radiotherapy to the treatment of various cancers. In this study, early response and acute reaction were analyzed. Methods : Eighteen patients treated with intracavitary hyperthermo-radiotherapy were as follows; 4 of esophageal cancer, 6 of uterine cervical cancer, 3 of rectal cancer, and 5 of others. Intracavitary hyperthermia was performed with Endoradiotherm 100A (OLYMPUS) once or twice a week with a total number of heating sessions ranging from 2 to 12 times. The heating was started just after the irradiation, and the temperature measured at the surface of applicator was kept at 42-44°C during the treatment for 30-40 min. External irradiation was performed in the majority of these 18 patients. Results : 9 cases achieved complete response (CR), 6 cases did partial response (PR) and 3 cases were no change (NC). Of CR 9 cases, 6 cases showed 2-year local control. There were 2 esophageal tumors, 2 cervical tumors, 1 rectal tumor, and 1 vaginal stump tumor among 2year local control cases. The treatment was interrupted in 2 patients from severe local pain during the heating. Severe vaginal mucositis occurred in 4 stump tumors. Conclusions : Intracavitary hyperthermoradiotherapy showed good early response for esophageal cancer and stump tumor. The advantages of intracavitary hyperthermia might be the reliability of heating for the treatment of localized tumors.
- 日本ハイパーサーミア学会の論文
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