Combination of Low Dose-Rate Brachytherapy and Mild Temperature Hyperthermia. A Basic Concept for Clinical Application.:-A Basic Concept for Clinical Application-

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This paper reviews experimental research on the combined use of low dose-rate (LDR) brachytherapy and mild temperature hyperthermia (MTH). The paper also refers to our basic concept, preliminary clinical results and further research on this combination therapy. In biological research in the past two decades, there is a general agreement that MTH around 41°C can reduce the LDR sparing effect. The potential advantages of combined use of MTH and LDR brachytherapy are (A) readily applicable to concurrent exposure, (B) greater repair inhibition rather than MTH with high dose-rate (HDR) irradiation, and (C) good distribution of both the radiation dose and temperature when interstitial hyperthermia can be applied. We recommend this combined treatment for large recurrent tumors with inhomogenious dose distribution. In our clinical results, half of the large recurrent tumors were able to be controlled. Further studies, which will clarify the best treatment schedule and produce better treatment devices, are desirable to facilitate clinical use.
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