Effect of Benzaldehyde on Survivals of Chinese Hamster V-79 Cells in Vitro from The Combined Treatment with Hyperthermia.

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(1) The effects of benzaldehyde (BA) in the slightly cytotoxic concentration on cell survivals from hyperthermia as observed in colony formation representing markedly enhanced thermosensitivity of Chinese hamster V-79 cells in vitro. (2) After incubation of benzylidene glucopyranose (BG) under condition of pH 3 for 22 hr, half an amount of BG was hydrolysed to BA as observed with the specific absorbance at 250 nm of BA. (3) BA is a hydrolysate of amygdaline that enhanced thermosensitivity. Other hand BG did not show any appreciable interaction for thermo-enhancement but showed no more than the additive effect. Adopted concentration of BA or BG was 1.8 mM. BG in 1.8mM was treated under pH 3 for 22 hr, resulting in half a BG was hydrolysed. It was designated BG*. (4) Indication of BA or its derivatives would be possible thermo-enhancer in human clinical interdisciplinary oncotherapy including hyperthermia.
日本ハイパーサーミア学会の論文