Hyperthermia Enhancement by Thermosensitive Liposome as a New Thermochemotherapy for Malignant Brain Tumor.
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概要
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Thermosensitive liposomes are microscopic vesicles that can release their contained drugs effectively in response to hyperthermia (HT). Previously we revealed the combination of thermosensitive liposome containing CDDP and local brain heating using RF interstitial antenna showed remarkable antitumor effects against rat malignant gliomas. A new liposome was prepared considering this drug delivery system as a clinical use. While a transition temperature of the conventional liposomes has been 42 or 43°C to enhance the synergistic effect of HT and antitumor drugs, the heated area above 42°C was localized in a narrow portion of human glioma. But the width of lower temperature area increased according to the distance from the RF antenna and the area of 40 °C extended up to the wide portion of the brain tumor. So we prepared a new liposome which can release adriamycin (ADR) above 40°C. As a result, this liposome showed significantly great antitumor effects against rat gliomas with the temperature of 40°C. This procedure 1) helps to deliver the antitumor drugs more widely to glioma and contributes to the synergistic effect of HT and antitumor drugs in the regions above 40 °C, 2) is effective in direct thermal killing in the regions above 43°C, 3) givesagoodchance tomanyantitumordrugs, such as ADR, which have not been used from the problem of blood brain barrier. 4) Moreover this new liposome could, be injected safely intraarterially. In conclusion, the advantage of this plan could outweigh the disadvantages of the conventional thermo-chemotherapy.
- 日本ハイパーサーミア学会の論文
日本ハイパーサーミア学会 | 論文
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