Long Duration Mild Hyperthermia as Adjuvant Therapy for Experimental Breast Tumors in Rats.

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The feasibility and efficacy of long duration-low temperature whole body hyperthermia (LL-WBH, at 40°C for 6 h) as adjuvant therapy was investigated in rats bearing highly metastatic mammary adenocarcinoma (MTLn 3). All animals in the non-surgery control group demonstrated a progression of axillary lymph node metastases (ALM) on day 24 after inoculation. In a preoperative treatment study, 67 % of the animals developed ALM in both the treatment and control groups, however, the local recurrence rate was significantly suppressed to 0% in the treated rats compared to the control (67%) (p < 0.05). In a postoperative treatment study, 30% and 33% developed ALM, in treatment and control groups, respectively (p < 0.01, compared to the non-surgery control), however, the incidence of local recurrence was 40% and 11 % for the treatment and control groups, respectively. No significant differences were seen between any of the groups (20-55 %) with respect to tumor cure. The authors thus conclude that LL-WBH appears to be a valuable adjuvant therapy to surgery, however, an ideal therapeutic design still needs to be developed for its clinical application. Therefore, additional studies of LL-WBH as an adjuvant treatment to surgery are called for.
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