A study on magnetic fine particles for microwave hyperthermia.
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概要
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We have developed magnetic fine particles for local heating technique for microwave hyperthermia. The aqueous dispersion of iron (II) iron (III) oxide fine particles was mixed with the aqueous gelatin solution at pH 5.0, which yielded the dispersion of iron (II) iron (III) oxide fine particles protected with gelatin (Gel-Mag fine particles) as magnetic fine particles. Gel-Mag fine particles were stable in physiological saline solution. Dispersion stability of Gel-Mag fine particles and the amount of gelatin adsorbed on iron (II) iron (III) oxide fine particles were measured. Larger amount of adsorbed gelatin resulted in larger dispersion stability of Gel-Mag fine particles.<BR>When the dispersion of Gel-Mag fine particles was made to flow into polyvinylchloride tube located in the electrically muscle-equivalent agar phantom model, the accumulation of Gel-Mag fine particles was observed on the inner wall of the tube under the direct magnetic field. The 430 MHz-microwave (input power, 5 W) was irradiated for 5 min with a wave-guide applicator to the phantom model with the orientation of the electric field of the microwave in the same direction as that of the direct magnetic field. In the presence of the accumulated Gel-Mag fine particles at 10 mm from the aperture of the applicator, temperature elevation was 175% to that in the absence of Gel-Mag fine particles. This result showed that absorbance of microwave in the accumulated Gel-Mag fine particles caused the temperature elevation in the phantom model. It has been concluded that the Gel-Mag fine particles are useful materials for microwave heating.
- 日本ハイパーサーミア学会の論文
日本ハイパーサーミア学会 | 論文
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